Three New Anthraquinones from Aerial Parts of Paederia scandens

Published on Apr 10, 2018in Chemistry of Natural Compounds0.653
· DOI :10.1007/S10600-018-2314-2
Xue Zhang3
Estimated H-index: 3
,
Hai-Feng Zhou3
Estimated H-index: 3
+ 2 AuthorsTong Wu1
Estimated H-index: 1
Source
Abstract
Three new anthraquinones, 1-methyl-2,4-dimethoxy-3-hydroxyanthraquinone (6), 1-methoxy-3-hydroxy-2-ethoxymethylanthraquinone (7), and 2-methyl-3-O-β-D-primeveroside (14), together with 15 known compounds, including seven anthraquinones, one iridoid glucoside, three phenolic compounds, three flavone glucosides, and one flavone, were isolated from Paederia scandens. The isolated compounds were elucidated by extensive spectroscopic methods. To the best of our knowledge, six known anthraquinones (1, 2, 5, 9, 10, and 13) and two known phenolic acids (4, 11) were isolated from this plant for the first time.
📖 Papers frequently viewed together
2 Citations
References14
Newest
#1Hang-Ying Ma (State Ethnic Affairs Commission)H-Index: 3
#2Li-Xuang LiuH-Index: 3
Last. Qiu-Fen Hu (State Ethnic Affairs Commission)H-Index: 20
view all 13 authors...
Two new anthraquinones, alataquinones A and B (1 and 2), together with two known anthraquinones (3 and 4), were isolated from the barks of Cassia alata. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1–4 exhibited moderate anti-TMV activity with inhibition rates in the range of 22.8–26.4%.
3 CitationsSource
#1Qinge MaH-Index: 8
#2Rongrui Wei (CPU: China Pharmaceutical University)H-Index: 5
Last. Xiuhuan GuoH-Index: 1
view all 5 authors...
4 CitationsSource
#1Changlong ZhuangH-Index: 3
#2Xinjie WangH-Index: 1
Last. Tong WuH-Index: 5
view all 5 authors...
Paederia scandens (Lour.) Merr. is a plant of the family Rubiaceae and genus Paederia. The aerial parts can be used as folk medicine for the treatment of pain and inflammation. The Chinese Pharmacopoeia (1977 edition) listed P. scandens as an official drug. Flavonoids 1 , iridoids 2, 3 , and triterpene saponins 4 were isolated in previous phytochemical studies of the plant. Recently, we have systematically investigated the chemical constituents of the aerial parts. This study was carried out wit...
3 CitationsSource
#1Milkyas Endale (UoN: University of Nairobi)H-Index: 4
#1Milkyas EndaleH-Index: 3
Last. Abiy YenesewH-Index: 26
view all 8 authors...
Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 μg/mL) and D6-strains (4.00 μg/mL) of Plasmodium falciparum and low cytotoxicity (>450 μg/mL, MCF-7 cell line). Chromatographic separation of the extract yielded nine anthraquinones, of which 5,6-dihydroxylucidin-11-O- methyl ether is new. Isolation of a munjistin derivative from ...
16 CitationsSource
#1Lishuang Lv (A&T: North Carolina Agricultural and Technical State University)H-Index: 10
#2Hua-Dong Chen (A&T: North Carolina Agricultural and Technical State University)H-Index: 18
Last. Shengmin Sang (A&T: North Carolina Agricultural and Technical State University)H-Index: 68
view all 4 authors...
Roots of Morinda citrifolia (Noni or Yor in Thai) have been used traditionally for thousands of years to treat chronic diseases such as cancer and heart disease. In this study, three new anthraquinones together with 15 known compounds were isolated from the roots of M. citrifolia (Rubiaceae). Their structures were established by spectroscopic methods, particularly 1D and 2D NMR techniques. Six known compounds, together with two new compounds (2 and 3) showed significant inhibitory effects on the...
28 CitationsSource
#1Vatcharin Rukachaisirikul (PSU: Prince of Songkla University)H-Index: 34
#2Nanthaphong Khamthong (PSU: Prince of Songkla University)H-Index: 6
Last. Kanyawim Kirtikara (Biotec)H-Index: 26
view all 8 authors...
Nigrosporanenes A (1) and B (2), two new cylohexene derivatives, and tyrosol (3) were isolated from the sea fan-derived fungus Nigrospora sp. PSU-F11, whereas five known compounds: 4-hydroxybenzoic acid (4), aplysiopsene D (5), 3-isochromanone (6), (−)-drimenin (7) and diketopiperazine derivative (8), were obtained from the fungus Nigrospora sp. PSU-F12. Their structures were established by spectroscopic evidence. We also tested their cytotoxic (on African green monkey kidney fibroblast and brea...
34 CitationsSource
#1Yan-Bin Wu (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 4
#2Cheng-Jian ZhengH-Index: 23
Last. Jin-Zhong WuH-Index: 11
view all 8 authors...
Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among ...
85 CitationsSource
#1Zühal Güvenalp (Atatürk University)H-Index: 15
#2Nurcan KiliçH-Index: 1
Last. Cavit KazazH-Index: 19
view all 3 authors...
From the aerial parts of Galium tortumense Ehrend & Schonb.-Tem., 8 iridoid glycosides, a flavonol glycoside, a oleanane-type triterpene acid, an ursan-type triterpene acid and a sterol were isolated. The structures of the compounds were elucidated by high field 1D and 2D NMR and EIMS spectroscopies.
63 Citations
#1Byeoung-Soo Park (SNU: Seoul National University)H-Index: 20
#2Hyun Kyung Lee (SNU: Seoul National University)H-Index: 18
Last. Jeong-Han Kim (SNU: Seoul National University)H-Index: 24
view all 8 authors...
Abstract The growth-inhibiting activity of Tabebuia impetiginosa Martius ex DC dried inner bark-derived constituents against Helicobacter pylori ATCC 43504 was examined using paper disc diffusion and minimum inhibitory concentration (MIC) bioassays. The activity of the isolated compounds was compared to that of the commercially available anti- Helicobacter pylori agents, amoxicillin, metronidazole, and tetracycline. The biologically active components of Tabebuia impetiginosa dried inner bark (ta...
106 CitationsSource
#1Bin Li (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 1
#2Dong-Ming Zhang (Peking Union Medical College)H-Index: 3
Last. Xiaoguang Chen (Peking Union Medical College)H-Index: 2
view all 4 authors...
Three new anthraquinone glycosides, lasianthuoside A (1), B (2), and C (3), were isolated from the root of Lasianthus acuminatissimus MERR., The structural elucidation of these anthraquinones was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Ten known compounds, damnacanthol (4), damnacanthol 11-methyl ether (5), damnacanthol-3-O-β-D-primeveroside (6), asperuloside (7), asperulosidic acid (8), deacetyl asperulosidic acid (9), a nonglycosidic iridoid (10), 2,6...
41 CitationsSource
Cited By3
Newest
#1Nguyen Quang Trung (University of Da Nang)H-Index: 1
#2Nguyen Minh Thong (University of Da Nang)H-Index: 8
Last. Quan V. Vo (University of Da Nang)H-Index: 10
view all 10 authors...
Anthraquinones (ANQs) isolated from Paederia plants are known to have antidiarrheal, antitussive, anthelmintic, analgesic, anti-inflammatory, antihyperlipidemic, antihyperglycaemic, and antimicrobial activities. The antioxidant properties were also noted but not confirmed thus far. In this study, the superoxide and hydroperoxide radical scavenging activities of six ANQs were evaluated using a computational approach. The results suggest that the ANQs exhibit low HOO• antiradical activity in all e...
Source
#1Huan Luo (Guangdong Pharmaceutical University)
#2Yi Wang (Guangdong Pharmaceutical University)H-Index: 1
Last. Xiangjiu He (Guangdong Pharmaceutical University)H-Index: 15
view all 6 authors...
Abstract Morinda (Morinda officinalis) is widely consumed as a health-care herb in Asia and reported to possess various biological activities. In this study, anti-inflammatory phytochemicals were investigated and two pairs of new methyl-2-naphthoate enantiomers (1a/1b, 2a/2b), one new anthraquinone (3), three new natural unknown anthraquinones (5-6, 23), and eighteen known anthraquinones were isolated and elucidated from the roots of morinda. Anti-inflammatory activities of the isolated compound...
Source
#1Qinge Ma (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 8
#2Rongrui Wei (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 7
Last. Zhipei SangH-Index: 8
view all 3 authors...
Three new naphthoquinones, namely 5,8-dihydroxy-7′-isopropyl-furan ring-1″-prenyl-naphthoquinone (1), 5,8-dihydroxy-7′-propenyl-furan ring-1″-isopropanol-naphthoquinone (2), and 5,8-dihydroxy-7′-is...
9 CitationsSource