Type V Collagen is Persistently Altered After Inguinal Hernia Repair.

Published on Apr 9, 2018in Scandinavian Journal of Surgery2.36
· DOI :10.1177/1457496918766694
Lea Lorentzen3
Estimated H-index: 3
(UCPH: University of Copenhagen),
N. A. Henriksen16
Estimated H-index: 16
(UCPH: University of Copenhagen)
+ 4 AuthorsLars N. Jorgensen55
Estimated H-index: 55
(UCPH: University of Copenhagen)
Background and Aims:Hernia formation is associated with alterations of collagen metabolism. Collagen synthesis and degradation cause a systemic release of products, which are measurable in serum. Recently, we reported changes in type V and IV collagen metabolisms in patients with inguinal and incisional hernia. The aim of this study was to determine if the altered collagen metabolism was persistent after hernia repair.Material and Methods:Patients who had undergone repairs for inguinal hernia (n = 11) or for incisional hernia (n = 17) were included in this study. Patients who had undergone elective cholecystectomy served as controls (n = 10). Whole venous blood was collected 35–55 months after operation. Biomarkers for type V collagen synthesis (Pro-C5) and degradation (C5M) and those for type IV collagen synthesis (P4NP) and degradation (C4M2) were measured by a solid-phase competitive assay.Results:The turnover of type V collagen (Pro-C5/C5M) was slightly higher postoperatively when compared to preopera...
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