127TiP Phase I study of neo-adjuvant Stereotactic Body Radiotherapy (SBRT) in operable patients with borderline resectable locally advanced NSCLC (LA-NSCLC) (LINNEARRE I STUDY: NCT02433574)

Background: Patients with NSCLC who undergo incomplete resection (R1) have significantly worse survival compared to those with complete resection (R0). The efficacy of Stereotactic Body Radiotherapy (SBRT) in treating small lung tumors is established, but its use as neo-adjuvant therapy in locally-advanced (LA)-NSCLC is not investigated. We hypothesized that pre-operative SBRT can be done safely and could improve rates of R0 resection in...