Regulation of Blood Pressure by Targeting Ca _V 1.2-Galectin-1 Protein Interaction

L-type CaV1.2 channels play crucial roles in the regulation of blood pressure. Galectin-1 (Gal-1) has been reported to bind to the I-II loop of CaV1.2 channels to reduce their current density. However, the mechanistic understanding for the downregulation of CaV1.2 channels by Gal-1 and whether Gal-1 plays a direct role in blood pressure regulation remain unclear.In vitro experiments involving coimmunoprecipitation, Western blot, patch-clamp...