Original paper

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

Volume: 128, Issue: 7, Pages: 3041 - 3052
Published: Jun 11, 2018
Abstract
Monogenic IFN-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN response gene signature, inflammatory organ damage, and high mortality. We used the JAK inhibitor baricitinib, with IFN-blocking activity in vitro, to ameliorate disease.Between October 2011 and February 2017, 10 patients with CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures), 4 patients with SAVI...
Paper Details
Title
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
Published Date
Jun 11, 2018
Volume
128
Issue
7
Pages
3041 - 3052
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