Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Published on Apr 13, 2018in Artificial Cells Nanomedicine and Biotechnology3.343
· DOI :10.1080/21691401.2018.1460372
Zhifang Zheng3
Estimated H-index: 3
(Southern Medical University),
Yishu Liu3
Estimated H-index: 3
(Third Military Medical University)
+ 4 AuthorsBiao Cheng5
Estimated H-index: 5
(Third Military Medical University)
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Abstract
AbstractDiabetic foot ulcers (DFUs) are a threat to human health and can lead to amputation and even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found to be beneficial for diabetic wound healing. As we demonstrated previously, polylactide–polyglycolide (PLGA) and cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. PLGA/CNC nanofiber membranes are novel materials that have not been used previously as NT carriers in diabetic wounds. This study aims to explore the therapeutic efficacy and possible mechanisms of NT-loaded PLGA/CNC nanofiber membranes in full-thickness skin wounds in spontaneously diabetic mice. The results showed that NT could be sustained released from NT-loaded PLGA/CNC composite nanofiber membranes for 2 weeks. NT-loaded PLGA/CNC composite nanofiber membranes induced more rapid healing than other control groups. After NT exposure, the histological scor...
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