Cholinergic neuron

Internal medicine

Pathology

Psychology

Neurology

Neuroscience

Immunology

Cholinergic

Oxidative stress

Inflammation

Amyloid (mycology)

Tau protein

Disease

Dementia

Alzheimer's disease

Medicine

Translational Neurodegeneration

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies.

Alzheimer’s disease hypothesis and related therapies