Injectable self-healing carboxymethyl chitosan-zinc supramolecular hydrogels and their antibacterial activity.

Published on Jul 15, 2018in International Journal of Biological Macromolecules6.953
· DOI :10.1016/J.IJBIOMAC.2018.04.025
Fazli Wahid15
Estimated H-index: 15
(Tianjin University of Science and Technology),
Ya-Ning Zhou3
Estimated H-index: 3
(Tianjin University of Science and Technology)
+ 3 AuthorsLi-Qiang Chu15
Estimated H-index: 15
(Tianjin University of Science and Technology)
Sources
Abstract
Abstract Injectable and self-healing hydrogels have found numerous applications in drug delivery, tissue engineering and 3D cell culture. Herein, we report an injectable self-healing carboxymethyl chitosan (CMCh) supramolecular hydrogels cross-linked by zinc ions (Zn2+). Supramolecular hydrogels were obtained by simple addition of metal ions solution to CMCh solution at an appropriate pH value. The mechanical properties of these hydrogels were adjustable by the concentration of Zn2+. For example, the hydrogel with the highest concentration of Zn2+ (CMCh-Zn4) showed strongest mechanical properties (storage modulus ~ 11,000 Pa) while hydrogel with the lowest concentration of Zn2+ (CMCh-Zn1) showed weakest mechanical properties (storage modulus ~ 220 Pa). As observed visually and confirmed rheologically, the CMCh-Zn1 hydrogel with the lowest Zn2+ concentration showed thixotropic property. CMCh-Zn1 hydrogel also presented injectable property. Moreover, the antibacterial properties of the prepared supramolecular hydrogels were studied against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) by agar well diffusion method. The results revealed Zn2+ dependent antibacterial properties against both kinds of strains. The inhibition zones were ranging from ~11–24 mm and ~10–22 mm against S. aureus and E. coli, respectively. We believe that the prepared supramolecular hydrogels could be used as a potential candidate in biomedical fields.
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