Inhalational anesthetics accelerate desensitization of acid-sensing ion channels
Abstract
Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by extracellular acidification. Inhibiting ASICs is neuroprotective in mouse models of ischemic stroke. As inhalational anesthetics interact with many ion channels and as some of them have neuroprotective effects, we hypothesized that inhalational anesthetics modulate ASICs. We expressed different homo- and heteromeric ASICs heterologously in Xenopus oocytes. We...
Paper Details
Title
Inhalational anesthetics accelerate desensitization of acid-sensing ion channels
Published Date
Jun 1, 2018
Journal
Volume
135
Pages
496 - 505
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