Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site.

Volume: 151, Pages: 482 - 494
Published: May 10, 2018
Abstract
Microtubules (composed of α- and β-tubulin heterodimers) play a pivotal role in mitosis and cell division, and are regarded as an excellent target for chemotherapeutic agents to treat cancer. There are four unique binding sites in tubulin to which taxanes, vinca alkaloids, laulimalide and colchicine bind respectively. While several tubulin inhibitors that bind to the taxane or vinca alkaloid binding sites have been approved by FDA, currently...
Paper Details
Title
Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site.
Published Date
May 10, 2018
Volume
151
Pages
482 - 494
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