DNA methylation loss in late-replicating domains is linked to mitotic cell division
Abstract
DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-associated, late-replicating regions termed partially methylated domains (PMDs). We profiled 39 diverse primary tumors and 8 matched adjacent tissues using whole-genome bisulfite sequencing (WGBS) and analyzed them alongside 343 additional human and 206 mouse WGBS datasets. We identified a local CpG sequence context associated with preferential hypomethylation in...
Paper Details
Title
DNA methylation loss in late-replicating domains is linked to mitotic cell division
Published Date
Apr 1, 2018
Journal
Volume
50
Issue
4
Pages
591 - 602
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