A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer
Abstract
Tropomyosin-related kinase A (TrkA) plays important roles in tumor cell growth and survival signaling and contributes to chemo-resistance in pancreatic cancer. Therefore, we developed KK5101, a novel TrkA target inhibitor and assessed its anti-cancer effects and investigated underlying mechanism of action in pancreatic cancer. KK5101 was characterized to inhibit TrkA selectively and potently by protein binding assay. It effectively inhibited the...
Paper Details
Title
A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer
Published Date
Jul 1, 2018
Journal
Volume
426
Pages
25 - 36
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