NSAID use and somatic exomic mutations in Barrett’s esophagus
Abstract
Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the metaplastic condition Barrett's esophagus (BE) and to lower the incidence and mortality of esophageal adenocarcinoma (EA). The esophagus is exposed to both intrinsic and extrinsic mutagens resulting from gastric reflux, chronic inflammation, and exposure to environmental carcinogens...
Paper Details
Title
NSAID use and somatic exomic mutations in Barrett’s esophagus
Published Date
Feb 27, 2018
Journal
Volume
10
Issue
1
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