Immunotherapy

Cancer immunotherapy

Transcription factor

Biology

Gene

Cancer

Innate immune system

Immunology

Interferon

IRF1

Cancer research

Genetics

Immune system

Interferon regulatory factors

Bioscience Reports

Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation. The different mechanisms underlying IRF-1 inactivation and their implications for human cancers and the potential importance of IRF-1 in immunotherapy are also summarized.

Interferon regulatory factor 1 inactivation in human cancer