Systematic Evaluation of Molecular Networks for Discovery of Disease Genes
Abstract
Gene networks are rapidly growing in size and number, raising the question of which networks are most appropriate for particular applications. Here, we evaluate 21 human genome-wide interaction networks for their ability to recover 446 disease gene sets identified through literature curation, gene expression profiling, or genome-wide association studies. While all networks have some ability to recover disease genes, we observe a wide range of...
Paper Details
Title
Systematic Evaluation of Molecular Networks for Discovery of Disease Genes
Published Date
Apr 1, 2018
Journal
Volume
6
Issue
4
Pages
484 - 495.e5
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