Original paper

Continuous Flow Asymmetric Hydrogenation with Supported Ionic Liquid Phase Catalysts Using Modified CO2 as the Mobile Phase: from Model Substrate to an Active Pharmaceutical Ingredient

Volume: 8, Issue: 4, Pages: 3297 - 3303
Published: Mar 16, 2018
Abstract
The continuous flow asymmetric hydrogenation of (hetero)aromatic enamides has been realized using a Rh-Quinaphos catalyst immobilized in a supported ionic liquid phase (SILP) and employing supercritical CO2 modified with toluene (modCO2) as the mobile phase. This approach allows expansion of the scope of the original SILP/scCO2 system to nonvolatile substrates with poor solubility in pure CO2. The potential of a SILP catalyst in combination with...
Paper Details
Title
Continuous Flow Asymmetric Hydrogenation with Supported Ionic Liquid Phase Catalysts Using Modified CO2 as the Mobile Phase: from Model Substrate to an Active Pharmaceutical Ingredient
Published Date
Mar 16, 2018
Volume
8
Issue
4
Pages
3297 - 3303
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