Potential targets for next generation antimicrobial glycoconjugate vaccines.
Abstract
Cell surface carbohydrates have been proven optimal targets for vaccine development. Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune response to the glycan moiety. Licensed glycoconjugate vaccines are produced by chemical conjugation of capsular polysaccharides to prevent meningitis caused by meningococcus, pneumococcus and Haemophilus influenzae type b. However, other classes of carbohydrates (O-antigens,...
Paper Details
Title
Potential targets for next generation antimicrobial glycoconjugate vaccines.
Published Date
May 1, 2018
Journal
Volume
42
Issue
3
Pages
388 - 423
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