Original paper

Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

Volume: 20, Issue: 3, Pages: 352 - 360
Published: Jan 22, 2018
Abstract
Although mitochondria are ubiquitous organelles, they exhibit tissue-specific morphology, dynamics and function. Here, we describe a robust approach to isolate mitochondria from specific cells of diverse tissue systems in Caenorhabditis elegans. Cell-specific mitochondrial affinity purification (CS-MAP) yields intact and functional mitochondria with exceptional purity and sensitivity (>96% enrichment, >96% purity, and single-cell and...
Paper Details
Title
Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism
Published Date
Jan 22, 2018
Volume
20
Issue
3
Pages
352 - 360
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