Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma

Volume: 18, Issue: 5, Pages: 335 - 345
Published: May 1, 2018
Abstract
Multiple myeloma (MM) is a malignancy of plasma cells that is typically chronic, and relapse is common. Current therapeutic strategies include combination and sequential treatments with corticosteroids, alkylating agents, proteasomal inhibitors, immunomodulators, and monoclonal antibodies. These drugs prolong survival but ultimately become ineffective. Exportin 1 (XPO1), a nuclear export protein, is overexpressed in MM cells, and knockdown...
Paper Details
Title
Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma
Published Date
May 1, 2018
Volume
18
Issue
5
Pages
335 - 345
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