Impact of various solid carriers and spray drying on pre/post compression properties of solid SNEDDS loaded with glimepiride: in vitro-ex vivo evaluation and cytotoxicity assessment.

Published on Feb 5, 2018in Drug Development and Industrial Pharmacy2.365
· DOI :10.1080/03639045.2018.1431656
Sarvi Yadav Rajesh4
Estimated H-index: 4
(LPU: Lovely Professional University),
Sachin Kumar Singh19
Estimated H-index: 19
(LPU: Lovely Professional University)
+ 7 AuthorsSaurabh Singh6
Estimated H-index: 6
(LPU: Lovely Professional University)
Sources
Abstract
AbstractDevelopment of self-nanoemulsifying drug delivery systems (SNEDDS) of glimepiride is reported with the aim to achieve its oral delivery. Lauroglycol FCC, Tween-80, and ethanol were used as oil, surfactant, and co-surfactant, respectively as independent variables. The optimized composition of SNEDDS formulation (F1) was 10% v/v Lauroglycol FCC, 45% v/v Tween 80, 45% v/v ethanol, and 0.005% w/v glimepiride. Further, the optimized liquid SNEDDS were solidified through spray drying using various hydrophilic and hydrophobic carriers. Among the various carriers, Aerosil 200 was found to provide desirable flow, compression, dissolution, and diffusion. Both, liquid and solid-SNEDDS have shown release of more than 90% within 10 min. Results of permeation studies performed on Caco-2 cell showed that optimized SNEDDS exhibited 1.54 times higher drug permeation amount and 0.57 times lower drug excretion amount than that of market tablets at 4 hours (p < .01). Further, the cytotoxicity study performed on Caco-...
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