Animal models of preeclampsia: an examination of usefulness and limitations based on the metabolic domino theory

Animal models of preeclampsia are widely used to elucidate the underlying pathology and investigate the clinical utility of drugs. Although a large body of data has been generated that supports their usefulness, animal models are not necessarily suitable for all research objectives. A more thorough understanding of advantages and disadvantages of each animal model will facilitate selection of appropriate models for a given study area, thereby...