Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial

Background Severe malaria is a leading cause of acquired neurodisability in Africa and is associated with reduced nitric oxide (NO) bioavailability. A neuroprotective role for inhaled NO has been reported in animal studies, and administration of inhaled NO in preterm neonates with respiratory distress syndrome is associated with a 47% reduced risk of cognitive impairment at two years of age. Methods A randomized double-blind placebo-controlled...