Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

Volume: 9, Issue: 1, Pages: 1127 - 1127
Published: Mar 19, 2018
Abstract
Despite tremendous efforts to develop stimuli-responsive enzyme delivery systems, their efficacy has been mostly limited to in vitro applications. Here we introduce, by using an approach of combining biomolecules with artificial compartments, a biomimetic strategy to create artificial organelles (AOs) as cellular implants, with endogenous stimuli-triggered enzymatic activity. AOs are produced by inserting protein gates in the membrane of...
Paper Details
Title
Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
Published Date
Mar 19, 2018
Volume
9
Issue
1
Pages
1127 - 1127
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