Differences in steady-state glutamate levels and variability between ‘non-task-active’ conditions: Evidence from 1H fMRS of the prefrontal cortex

Proton functional magnetic resonance spectroscopy (1H fMRS) is a noninvasive neuroimaging technique capable of detecting dynamic changes in glutamate related to task-related demands at a temporal resolution under 1 min. Several recent 1H fMRS studies demonstrated elevated steady-state levels of glutamate of 2% or greater during different ‘task-active’ conditions, relative to a ‘non-task-active’ control condition. However, the ‘control’ condition...