PD-L1 Signal Transduction Mechanisms in Cancer Cells

Background: Programmed death-1 ligand 1 (PD-L1) is one of the most important immunoregulatory molecules expressed on the cell surface of many cell types under a variety of physiological and pathological conditions. One of its key functions is the inhibition of T cell effector activities by binding with programmed death-1 (PD-1) expressed on the surface of activated T and B cells. After its binding, PD-1 inhibits signal transduction of the T cell...