Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma
Abstract
Free serum copper correlates with tumor incidence and progression of human cancers, including hepatocellular carcinoma (HCC). Copper extracellular uptake is provided by the transporter CTR1, whose expression is regulated to avoid excessive intracellular copper entry. Inadequate copper serum concentration is involved in the pathogenesis of Non Alcoholic Fatty Liver Disease (NAFLD), which is becoming a major cause of liver damage progression and...
Paper Details
Title
Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma
Published Date
Jan 20, 2018
Journal
Volume
9
Issue
10
Pages
9325 - 9343
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Notes
History