Best practice guidelines on management of mild neonatal encephalopathy: Is it really mild?

Neonatal hypoxic ischemic encephalopathy (HIE) is difficult to classify within the narrow therapeutic window of hypothermia. Neurophysiological biomarkers are needed for timely differentiation of encephalopathy severity within the short therapeutic window for initiation of hypothermia therapy.A novel analysis of mean Phase Amplitude Coupling index, PACm, of amplitudes high frequencies (12–30 Hz) coupled with phases of low (1,2 Hz) frequencies...