Inhibiting pulmonary metastasis of breast cancer based on dual-targeting graphene oxide with high stability and drug loading capacity

In this study, heparin and polyethyleneimine–folic acid modified graphene oxide was designed and synthesized as a dual-targeting biomaterial to load doxorubicin ([email protected]) with high loading capacity for enhanced cellular uptake. GDC0941, a phosphatidylinositide 3-kinase/Akt phosphorylation inhibitor, was selected to enhance anti-metastasis effect of [email protected] via down-regulating expression of matrix metalloproteinase. Modified...