Cancer

Internal medicine

Pathology

Immunology

Dysplasia

Intestinal metaplasia

Hyperplasia

Gastritis

Stomach

Autoimmunity

Atrophic gastritis

Chronic gastritis

Autoimmune Gastritis

Medicine

Immune system

Gastroenterology

International Journal of Molecular Sciences

Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Here, we review the association of autoimmune gastritis with gastric cancer and other autoimmune features present in gastric neoplasms.

Autoimmunity and Gastric Cancer