Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
Abstract
Genome-wide association studies (GWAS) have identified approximately 100 breast cancer risk loci. Translating these findings into a greater understanding of the mechanisms that influence disease risk requires identification of the genes or non-coding RNAs that mediate these associations. Here, we use Capture Hi-C (CHi-C) to annotate 63 loci; we identify 110 putative target genes at 33 loci. To assess the support for these target genes in other...
Paper Details
Title
Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
Published Date
Mar 12, 2018
Journal
Volume
9
Issue
1
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