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Spider silk

SILK

Spider

Nature Reviews Materials

All spiders produce protein-based biopolymer fibres that we call silk. The most studied of these silks is spider dragline silk, which is very tough and relatively abundant compared with other types of spider silks. Considerable research has been devoted to understanding the relationship between the molecular structure and mechanical properties of spider dragline silks. In this Review, we overview experimental and computational studies that have provided a wealth of detail at the molecular level on the highly conserved repetitive core and terminal regions of spider dragline silk. We also discuss the role of the nanocrystalline β-sheets and amorphous regions in determining the properties of spider silk fibres, endowing them with strength and elasticity. Additionally, we outline imaging techniques and modelling studies that elucidate the importance of the hierarchical structure of silk fibres at the molecular level. These insights into structure–function relationships can guide the reverse engineering of spider silk to enable the production of superior synthetic fibres. Experimental and computational studies reveal numerous aspects of the molecular and hierarchical structure of spider silk and of its molecular dynamics. In this Review, we discuss the structure–function relationships of spider silk that can be elucidated from these studies and how this knowledge may enable the reverse engineering of spider silk.

Uncovering the structure–function relationship in spider silk