Pretreatment with catalpol attenuates cardiac dysfunction following myocardial infarction through regulating apelin/APJ signaling pathway and inhibiting cardiomyocyte apoptosis in rats
Abstract
To investigate the effects and mechanisms of catalpol on cardiac function in rats with isoproterenol (ISO)-induced myocardial infarction (MI).Adult male Wistar rats were divided into four groups: control group, ISO group, catalpol (L, low dose) group, and catalpol (H, high dose) group. Isoproterenol (85 mg/kg) was injected subcutaneously for 2 consecutive days to induce experimental MI. At the end of experiment, the effects of catalpol on...
Paper Details
Title
Pretreatment with catalpol attenuates cardiac dysfunction following myocardial infarction through regulating apelin/APJ signaling pathway and inhibiting cardiomyocyte apoptosis in rats
Published Date
Jan 1, 2018
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