Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury

Volume: 3, Issue: 3, Pages: 2652 - 2660
Published: Mar 6, 2018
Abstract
This study aimed to novelly design and synthesize an amide derivative as a potential substitute of celastrol (CLT). We constituted the compound celastrol-glucosamine (CLG) by conjugating 1-(2-aminoethoxy)-2-glucosamine to celastrol (CLT) and confirmed its chemical structure by 1H NMR, 13C NMR, and LC-MS/MS. Then, the potential efficacy of the CLG was investigated on renal ischemia-reperfusion injury animal models. The results demonstrated that...
Paper Details
Title
Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury
Published Date
Mar 6, 2018
Journal
Volume
3
Issue
3
Pages
2652 - 2660
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