MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production
Abstract
Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots (caPTH1ROt) and in bones from mice exposed to elevated PTH levels but not in mice lacking [conditional knockout (cKO)] the PTH1R in Ots (cKOPTH1ROt)....
Paper Details
Title
MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production
Published Date
Jan 17, 2018
Journal
Volume
32
Issue
5
Pages
2878 - 2890
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