Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

Volume: 215, Issue: 4, Pages: 1115 - 1133
Published: Apr 2, 2018
Abstract
Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)-mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear skin dermis are dominated by DT-sensitive, melanin-laden cells that have been missed in previous studies and correspond to macrophages that have ingested melanosomes from...
Paper Details
Title
Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
Published Date
Apr 2, 2018
Volume
215
Issue
4
Pages
1115 - 1133
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