Messenger RNA

Translation (biology)

RNA methylation

Methylation

Biology

Gene

Embryonic stem cell

Cytoplasm

Gene knockdown

Cell nucleus

RNA-binding protein

RNA splicing

Nuclear export signal

Cell biology

Genetics

Methyltransferase

Molecular Cell

Wen et al. show that Zc3h13 is a critical RNA m6A regulator that is part of an evolutionarily conserved complex containing WTAP, Virilizer, and Hakai. Zc3h13 anchors this complex in the nucleus to facilitate m6A methylation and mESC pluripotency.

Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal