Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow
Abstract
Hematopoietic stem and progenitor cell (HSPC) functions are regulated by a specialized microenvironment in the bone marrow - the hematopoietic stem cell niche - of which the extracellular matrix (ECM) is an integral component. We describe here the localization of ECM molecules, in particular the laminin α4, α3 and α5 containing isoforms in the bone marrow. Laminin 421 (composed of laminin α4, β2, γ1 chains) is identified as a major component of...
Paper Details
Title
Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow
Published Date
Apr 1, 2018
Journal
Volume
67
Pages
47 - 62
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