Immunological profile of systemic effects after radiofrequency ablation of locally advanced pancreatic cancer: Study design and preliminary results

Radiofrequency is a local ablative method that has been applied in many unresectable or metastatic solid tumors. Our group has shown the feasibility and safety of radiofrequency ablation (RFA) of locally advanced pancreatic cancer (LAPC). Retrospective data show a positive impact on survival but prospective results are still under evaluation. RFA causes focal hyper-thermic injury which affects the tumor microenvironment and cells. Studies have...