Anabolism

Function (biology)

Metabolic pathway

In vitro

Immunology

Macrophage

Effector

Biochemistry

Metabolism

Biology

Immune system

Cell biology

Catabolism

Frontiers in Immunology

Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic pathways generating energy and biosynthetic precursors required for growth and general cellular maintenance. However, growing literature provide evidence of a much broader role for metabolic reactions and processes in controlling immunological effector functions. Much of this research into immunometabolism has focused on macrophages, cells that are central in pro- as well as anti-inflammatory responses, responses that in turn are a direct result of metabolic reprogramming. As we learn more about the precise role of metabolic pathways and pathway intermediates in immune function, a novel opportunity to target immunometabolism therapeutically has emerged. Here we review the current understanding of the regulation of macrophage function through metabolic remodelling.

Metabolic Modulation in Macrophage Effector Function