Signaling function of PRC2 is essential for TCR-driven T cell responses
Volume: 215, Issue: 4, Pages: 1101 - 1113
Published: Mar 9, 2018
Abstract
Differentiation and activation of T cells require the activity of numerous histone lysine methyltransferases (HMT) that control the transcriptional T cell output. One of the most potent regulators of T cell differentiation is the HMT Ezh2. Ezh2 is a key enzymatic component of polycomb repressive complex 2 (PRC2), which silences gene expression by histone H3 di/tri-methylation at lysine 27. Surprisingly, in many cell types, including T cells,...
Paper Details
Title
Signaling function of PRC2 is essential for TCR-driven T cell responses
Published Date
Mar 9, 2018
Volume
215
Issue
4
Pages
1101 - 1113
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