TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation
Abstract
The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used as recently as in the Syrian conflict, no mechanism-based antidotes against SM are available. Recent studies demonstrated that Transient Receptor Potential Ankyrin 1 (TRPA1), a chemosensory...
Paper Details
Title
TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation
Published Date
Sep 1, 2018
Journal
Volume
293
Pages
140 - 148
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