A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.

Volume: 36, Issue: 3, Pages: 258 - 264
Published: Mar 1, 2018
Abstract
Nanoscale robots have potential as intelligent drug delivery systems that respond to molecular triggers. Using DNA origami we constructed an autonomous DNA robot programmed to transport payloads and present them specifically in tumors. Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells, and the blood coagulation protease thrombin within...
Paper Details
Title
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Published Date
Mar 1, 2018
Volume
36
Issue
3
Pages
258 - 264
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