Characterizing eutectic mixtures of gliclazide with succinic acid prepared by electrospray deposition and liquid assisted grinding methods

As a new method for improving dissolution, we have utilized electrospray deposition (ESD) to integrate eutectic formation with nanosizing. Gliclazide (GCZ) was used as a poorly soluble drug and succinic acid (SUC) as a water soluble carrier. A binary phase diagram was developed for the GCZ-SUC system. Eutectic mixtures (EMs) were prepared by liquid assisted grinding (LAG-EM) and electrospray deposition (ESD-EM). The effects of solvent type and...