DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Abstract
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We...
Paper Details
Title
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Published Date
Jan 5, 2018
Journal
Volume
4
Issue
1
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