A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma

Introduction Since the majority of patients are diagnosed at an advanced stage, ovarian cancer remains the most lethal gynecologic malignancy. There is no single biomarker with the sensitivity and specificity required for effective cancer screening; therefore, we investigated a panel of novel biomarkers for the early detection of high-grade serous ovarian carcinoma. Methods Twelve serum biomarkers with high differential gene expression and...