Cross-fibrillation of insulin and amyloid β on chiral surfaces: Chirality affects aggregation kinetics and cytotoxicity

Recent clinical and epidemiological research has shown that insulin is associated with the pathological mechanisms of Alzheimer’s disease (AD) and can protect against the oxidative stress triggered by amyloid-β peptide (Aβ). Herein, we present a systematic study on how the cross-fibrillation of insulin and Aβ is influenced by the surface chirality of an interface designed to mimic their aggregation on the cytomembrane. Intriguingly, the surface...