Internal medicine

Retrospective cohort study

Pediatrics

Cohort study

Hazard ratio

Virus

Disease

Dementia

Population

Immunology

Cohort

Herpes simplex virus

Confidence interval

Proportional hazards model

Medicine

Environmental health

Neurotherapeutics

This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using Taiwan's National Health Insurance Research Database (NHIRD). We enrolled a total of 33,448 subjects, and identified 8362 with newly diagnosed HSV infections and 25,086 randomly selected sex- and age-matched controls without HSV infections in a ratio of 1:3, selected from January 1, to December 31, 2000.

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan