PARP10 suppresses tumor metastasis through regulation of Aurora A activity
Abstract
ADP-ribosylation, including poly-ADP-ribosylation (PARylation) and mono-ADP-ribosylation (MARylation), is a multifunctional post-translational modification catalyzed by intracellular ADP-ribosyltransferases (ARTDs or PARPs). Although PARylation has been investigated most thoroughly, the function of MARylation is currently largely undefined. Here, we provide evidences that deficiency of PARP10, a mono-ADP-ribosyltransferase, markedly increased...
Paper Details
Title
PARP10 suppresses tumor metastasis through regulation of Aurora A activity
Published Date
Mar 8, 2018
Journal
Volume
37
Issue
22
Pages
2921 - 2935
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