Microenvironmental cues enhance mesenchymal stem cell-mediated immunomodulation and regulatory T-cell expansion
Abstract
Mesenchymal stem cells (MSCs) are known to both have powerful immunosuppressive properties and promote allograft tolerance. Determining the environmental oxygen tension and inflammatory conditions under which MSCs are optimally primed for this immunosuppressive function is essential to their utilization in promoting graft tolerance. Of particular interest is the mechanisms governing the interaction between MSCs and regulatory T cells (Tregs),...
Paper Details
Title
Microenvironmental cues enhance mesenchymal stem cell-mediated immunomodulation and regulatory T-cell expansion
Published Date
Mar 7, 2018
Journal
Volume
13
Issue
3
Pages
e0193178 - e0193178
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