Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

Structures of the voltage-gated and phosphatidylinositol 3,5-bisphosphate-activated mouse two-pore channel TPC1 in apo and ligand-bound states provide insights into the selectivity and gating mechanisms of mammalian two-pore channels. Two-pore channels (TPCs) are organellar voltage-dependent ion channels that are widely expressed in both animals and plants. In mammals, TPC1 and TPC2 regulate the physiological functions of the endolysosomal...